mouse CRKRS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cdk12.
shADV-256135
Ad-m-CRKRS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cdk12 (cyclin-dependent kinase 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810022J16Rik; AI646528; Crk7; Crkrs; D11Ertd752e; Pksc
Description (Vector)
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.
Gene ID
69131
Gene Name (Vector)
cyclin-dependent kinase 12
Gene Symbol
Cdk12
ORF Size (aa)
3777
ORF Size (bp)
3777 bp
RefSeq ID
NM_026952
RefSeq Synonyms
NM_026952, NM_001109628, NM_001109626, BC116645,
Species
mouse
UniGene ID
Mm.260516
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.