human DDIT4 Over-expression AAV

Name 
AAV-h-DDIT4
Cat No 
AAV-206707
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DDIT4.

AAV-206707
AAV-h-DDIT4

Ready-to-use AAV expressing Human DDIT4 (DNA damage inducible transcript 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Dig2; DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1; REDD1; REDD-1
Description (eCommerce)
REDD1 (regulated in development and DNA damage response 1) is a direct transcriptional target of HIF. It plays a role in the TSC/mTOR pathway as a regulator upstream of the TSC1/2 complex. In response to both hypoxia and energy stress, REDD1 inhibits mTOR activity in a TSC-dependent manner. Alternative names for REDD1 include DDIT4, DNA-damage-inducible transcript 4 protein, and RTP801.
Gene ID
54541
Gene Name (eCommerce)
DNA damage inducible transcript 4
Gene Name (Vector)
DNA damage inducible transcript 4
Gene Symbol
DDIT4
HGNC ID
HGNC:24944
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
699
ORF Size (bp)
699 bp
Protein Name (eCommerce)
DNA damage-inducible transcript 4 protein
RefSeq ID
NM_019058
RefSeq Synonyms
NM_019058, BC015236, BC007714, BC000708,
Research Areas
Apoptosis,Brain Development,Cancer,Host-Virus Interactions,Hypoxia,MicroRNAs in Cancer,Mitochondrion,mTOR Signaling,Neurobiology,Neurodevelopment,NGF Signaling,PI3K/Akt Signaling,Response to Virus,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
REDD1 (regulated in development and DNA damage response 1) is a direct transcriptional target of HIF. It plays a role in the TSC/mTOR pathway as a regulator upstream of the TSC1/2 complex. In response to both hypoxia and energy stress, REDD1 inhibits mTOR activity in a TSC-dependent manner. Alternative names for REDD1 include DDIT4, DNA-damage-inducible transcript 4 protein, and RTP801.
UniGene ID
Hs.523012
UniProt ID (eCommerce)
Q9NX09

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.