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human COPS3 shRNA silencing AAV

Name 
AAV-h-COPS3-shRNA
Cat No 
shAAV-205766
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human COPS3.

shAAV-205766
AAV-h-COPS3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COPS3 (COP9 signalosome subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 signalosome complex subunit 3; CSN3; JAB1-containing signalosome subunit 3; SGN3; signalosome subunit 3
Description (eCommerce)
CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
Description (Vector)
COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
8533
Gene Name (eCommerce)
COP9 signalosome subunit 3
Gene Name (Vector)
COP9 signalosome subunit 3
Gene Symbol
COPS3
HGNC ID
HGNC:2239
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1272
ORF Size (bp)
1272 bp
Protein Name (eCommerce)
COP9 signalosome complex subunit 3
RefSeq ID
NM_003653
RefSeq Synonyms
NM_003653, NM_001316358, NM_001316357, NM_001316356, NM_001316355, NM_001316354, NM_001199125, BC001891,
Research Areas
Neurobiology,Signal Transduction,TNF Signaling
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
UniGene ID
Hs.6076
UniProt ID (eCommerce)
Q9UNS2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.