mouse COPS3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cops3.
shAAV-255917
AAV-m-COPS3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cops3 (COP9 signalosome subunit 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Csn3; Sgn3
Description (Vector)
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Gene ID
26572
Gene Name (Vector)
COP9 signalosome subunit 3
Gene Symbol
Cops3
ORF Size (aa)
1272
ORF Size (bp)
1272 bp
RefSeq ID
NM_011991
RefSeq Synonyms
NM_011991, BC068179,
Species
mouse
UniGene ID
Mm.40
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.