human CLDN12 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLDN12.
shAAV-205365
AAV-h-CLDN12-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLDN12 (claudin 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
CLDN12 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. CLDN12 is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.
Gene ID
9069
Gene Name (Vector)
claudin 12
Gene Symbol
CLDN12
HGNC ID
HGNC:2034
ORF Size (aa)
735
ORF Size (bp)
735 bp
RefSeq ID
NM_012129
RefSeq Synonyms
NM_012129, NM_001185073, NM_001185072, BC068532, BC036754,
Species
human
UniGene ID
Hs.258576
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.