human CHST8 shRNA silencing AAV

Name
AAV-h-CHST8-shRNA

Cat No
shAAV-205254

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CHST8.

shAAV-205254

AAV-h-CHST8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHST8 (carbohydrate sulfotransferase 8). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GalNAc4ST; GALNAC4ST1; PSS3

Description (Vector)

CHST8 belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene.

Gene ID

64377

Gene Name (Vector)

carbohydrate sulfotransferase 8

Gene Symbol

CHST8

HGNC ID

HGNC:15993

ORF Size (aa)

1275

ORF Size (bp)

1275 bp

RefSeq ID

NM_022467

RefSeq Synonyms

NM_022467, NM_001127896, NM_001127895, BC018723, BC014250, BC011380,

Species

human

UniGene ID

Hs.165724

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.