human CHRFAM7A shRNA silencing AAV

Name
AAV-h-CHRFAM7A-shRNA

Cat No
shAAV-205193

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CHRFAM7A.

shAAV-205193

AAV-h-CHRFAM7A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CHRNA7; CHRNA7-DR1; D-10

Description (Vector)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Gene ID

89832

Gene Name (Vector)

CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion

Gene Symbol

CHRFAM7A

HGNC ID

HGNC:15781

ORF Size (aa)

966

RefSeq ID

NM_139320

RefSeq Synonyms

NM_148911, NM_139320, BC101348, BC101347, BC101346, BC101345,

Species

human

UniGene ID

Hs.510853

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.