human DBNL Over-expression AAV

Name 
AAV-h-DBNL
Cat No 
AAV-206626
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DBNL.

AAV-206626
AAV-h-DBNL

Ready-to-use AAV expressing Human DBNL (drebrin like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ABP1; actin-binding protein 1; cervical mucin-associated protein; cervical SH3P7; drebrin-F; drebrin-like protein; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; SH3P7; src homology 3 domain-containing protein HIP-55
Description (eCommerce)
HIP55 (HPK1-interacting protein of 55 kDa) is an actin-binding adapter protein that may act as a common effector of antigen receptor-signaling pathways in leukocytes. The association of HIP55 with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. HIP55 acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJU6].
Gene ID
28988
Gene Name (eCommerce)
drebrin like
Gene Name (Vector)
drebrin like
Gene Symbol
DBNL
HGNC ID
HGNC:2696
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Drebrin-like protein
RefSeq ID
NM_014063
RefSeq Synonyms
NM_014063, NM_001284315, NM_001284313, NM_001122956, NM_001014436, BC031687, BC011677,
Research Areas
Apoptosis,Cytoskeleton,Golgi Apparatus,Immunology,Neurobiology,Signal Transduction,Synapse,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
HIP55 (HPK1-interacting protein of 55 kDa) is an actin-binding adapter protein that may act as a common effector of antigen receptor-signaling pathways in leukocytes. The association of HIP55 with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. HIP55 acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJU6].
UniGene ID
Hs.436500
UniProt ID (eCommerce)
Q9UJU6

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.