human CDC45L shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CDC45.
shAAV-204776
AAV-h-CDC45L-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CDC45 (cell division cycle 45). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDC45L; CDC45L2; MGORS7; PORC-PI-1
Description (Vector)
CDC45 was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8318
Gene Name (Vector)
cell division cycle 45
Gene Symbol
CDC45
HGNC ID
HGNC:1739
ORF Size (aa)
1701
ORF Size (bp)
1701 bp
RefSeq ID
NM_003504
RefSeq Synonyms
NM_003504, NM_001178011, NM_001178010, BC010022, BC006232,
Species
human
UniGene ID
Hs.474217
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.