human CDC42EP4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CDC42EP4.
shAAV-204768
AAV-h-CDC42EP4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CDC42EP4 (CDC42 effector protein 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
binder of Rho GTPases 4; BORG4; CDC42 effector protein (Rho GTPase binding) 4; cdc42 effector protein 4; CEP4; KAIA1777
Description (eCommerce)
BORG4 (binder of Rho GTPases 4) is part of a family of proteins that function as negative regulators of CDC42 Rho GTPase signaling. The Borg family of proteins are also known as CEPs (Cdc effector proteins) and have been shown to act downstream of Cdc42 to influence the assembly of actin filaments and changes in cell shape.
Description (Vector)
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.
Gene ID
23580
Gene Name (eCommerce)
CDC42 effector protein 4
Gene Name (Vector)
CDC42 effector protein 4
Gene Symbol
CDC42EP4
HGNC ID
HGNC:17147
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1071
Protein Name (eCommerce)
Cdc42 effector protein 4
RefSeq ID
NM_012121
RefSeq Synonyms
NM_012121, BC010451, BC002774,
Research Areas
Cytoskeleton,Rho Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
BORG4 (binder of Rho GTPases 4) is part of a family of proteins that function as negative regulators of CDC42 Rho GTPase signaling. The Borg family of proteins are also known as CEPs (Cdc effector proteins) and have been shown to act downstream of Cdc42 to influence the assembly of actin filaments and changes in cell shape.
UniGene ID
Hs.3903
UniProt ID (eCommerce)
Q9H3Q1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.