human CD40 shRNA silencing AAV

Name
AAV-h-CD40-shRNA

Cat No
shAAV-204653

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CD40.

shAAV-204653

AAV-h-CD40-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD40 (CD40 molecule). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5

Description (eCommerce)

CD40 is a member of the TNF-receptor superfamily. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. [provided by RefSeq, Nov 2014] [taken from NCBI Entrez Gene (Gene ID: 958)].

Description (Vector)

CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene ID

958

Gene Name (eCommerce)

CD40 molecule

Gene Name (Vector)

CD40 molecule

Gene Symbol

CD40

HGNC ID

HGNC:11919

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

834

ORF Size (bp)

834 bp

Protein Name (eCommerce)

Tumor necrosis factor receptor superfamily member 5

RefSeq ID

NM_001250

RefSeq Synonyms

NM_152854, NM_001322422, NM_001322421, NM_001302753, NM_001250, BC064518, BC012419,

Research Areas

Apoptosis,Cancer,Cardiology,Cardiovascular,CD40 Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,NF-kB Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer

Research Areas (Faceted)

cancer,signal_transduction,cell_biology,cardiovascular,signal_transduction,immunology,infectious_disease,immunology,signal_transduction,cancer,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.472860

UniProt ID (eCommerce)

P25942

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.