human CCNB1 shRNA silencing AAV

Name 
AAV-h-CCNB1-shRNA
Cat No 
shAAV-204475
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CCNB1.

shAAV-204475
AAV-h-CCNB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCNB1 (cyclin B1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CCNB; G2/mitotic-specific cyclin-B1
Description (eCommerce)
Cyclin B1/CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P14635].
Description (Vector)
CCNB1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
Gene ID
891
Gene Name (eCommerce)
cyclin B1
Gene Name (Vector)
cyclin B1
Gene Symbol
CCNB1
HGNC ID
HGNC:1579
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1302
ORF Size (bp)
1302 bp
Protein Name (eCommerce)
G2/mitotic-specific cyclin-B1
RefSeq ID
NM_031966
RefSeq Synonyms
NM_031966, BC006510,
Research Areas
Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cell Division,Cytoskeleton,DNA Damage/Repair,FoxO Signaling,Gene Expression,Golgi Apparatus,Hedgehog Signaling,Histone Modification,Hypoxia,Immunology,Interleukin Signaling,Meiosis,p53 Signaling,PLK1 Signaling,Replication,RNA Processing,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Cyclin B1/CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P14635].
UniGene ID
Hs.23960
UniProt ID (eCommerce)
P14635

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.