human MCU shRNA silencing AAV

Name
AAV-h-MCU-shRNA

Cat No
shAAV-204228

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MCU.

shAAV-204228

AAV-h-MCU-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MCU (mitochondrial calcium uniporter). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C10orf42;calcium uniporter protein, mitochondrial;CCDC109A;coiled-coil domain-containing protein 109A;HsMCU

Description (eCommerce)

MCU is a channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix. MCU is involved in several processes, including cellular response to calcium ion starvation, positive regulation of mitochondrial calcium ion concentration, and positive regulation of mitochondrial fission. [taken from NCBI Entrez Gene (Gene ID: 90550)].

Description (Vector)

MCU encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Gene ID

90550

Gene Name (eCommerce)

mitochondrial calcium uniporter

Gene Name (Vector)

mitochondrial calcium uniporter

Gene Symbol

MCU

HGNC ID

HGNC:23526

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1056

ORF Size (bp)

1056 bp

Protein Name (eCommerce)

Calcium uniporter protein, mitochondrial

RefSeq ID

NM_138357

RefSeq Synonyms

NM_138357, NM_001270680, NM_001270679, BC034235,

Research Areas (Faceted)

cell_biology

Species

human

UniGene ID

Hs.591366

UniProt ID (eCommerce)

Q8NE86

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.