human CASQ2 shRNA silencing AAV

Name
AAV-h-CASQ2-shRNA

Cat No
shAAV-204130

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CASQ2.

shAAV-204130

AAV-h-CASQ2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASQ2 (calsequestrin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PDIB2

Description (Vector)

CASQ2 specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.

Gene ID

845

Gene Name (Vector)

calsequestrin 2

Gene Symbol

CASQ2

HGNC ID

HGNC:1513

ORF Size (aa)

1200

ORF Size (bp)

1200 bp

RefSeq ID

NM_001232

RefSeq Synonyms

NM_001232, BC022288,

Species

human

UniGene ID

Hs.57975

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.