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human C9ORF142 shRNA silencing AAV

Name 
AAV-h-C9ORF142-shRNA
Cat No 
shAAV-203791
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human C9orf142.

shAAV-203791
AAV-h-C9ORF142-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human C9orf142 (chromosome 9 open reading frame 142). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C9orf142; paralog of XRCC4 and XLF; protein PAXX; XLS; XRCC4-like small protein
Description (eCommerce)
C9orf142 is involved in DNA non-homologous end joining (NHEJ). It may act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break (DSB) sites [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUH6].
Gene ID
286257
Gene Name (eCommerce)
PAXX, non-homologous end joining factor
Gene Name (Vector)
chromosome 9 open reading frame 142
Gene Symbol
C9orf142
HGNC ID
HGNC:27849
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
615
ORF Size (bp)
615 bp
Protein Name (eCommerce)
Protein PAXX
RefSeq ID
NM_183241
RefSeq Synonyms
NM_183241, NM_001329678, BC002613,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
C9orf142 is involved in DNA non-homologous end joining (NHEJ). It may act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break (DSB) sites [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUH6].
UniGene ID
Hs.409582
UniProt ID (eCommerce)
Q9BUH6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.