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human C8ORF4 shRNA silencing AAV

Name 
AAV-h-C8ORF4-shRNA
Cat No 
shAAV-203725
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human C8orf4.

shAAV-203725
AAV-h-C8ORF4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human C8orf4 (chromosome 8 open reading frame 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
TC-1; TC1
Description (Vector)
C8orf4 encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Gene ID
56892
Gene Name (Vector)
chromosome 8 open reading frame 4
Gene Symbol
C8orf4
HGNC ID
HGNC:1357
ORF Size (aa)
321
ORF Size (bp)
321 bp
RefSeq ID
NM_020130
RefSeq Synonyms
NM_020130, BC021672, BC020623,
Species
human
UniGene ID
Hs.591849

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.