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human DOCK2 Adenovirus

Name 
Ad-h-DOCK2
Cat No 
ADV-207225
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DOCK2.

ADV-207225
Ad-h-DOCK2

Ready-to-use Adenovirus expressing Human DOCK2 (dedicator of cytokinesis 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2; IMD40
Description (eCommerce)
Dedicator of cytokinesis protein 2 (DOCK2) is Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. DOCK2 activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK2 may also participate in IL2 transcriptional activation via the activation of RAC2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92608].
Description (Vector)
DOCK2 belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.
Gene ID
1794
Gene Name (eCommerce)
dedicator of cytokinesis 2
Gene Name (Vector)
dedicator of cytokinesis 2
Gene Symbol
DOCK2
HGNC ID
HGNC:2988
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5493
ORF Size (bp)
5493 bp
Protein Name (eCommerce)
Dedicator of cytokinesis protein 2
RefSeq ID
NM_004946
RefSeq Synonyms
NM_004946, BC113457, BC104900,
Research Areas
Cytoskeleton,Host-Virus Interactions,Immunology,Interleukin Signaling,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Dedicator of cytokinesis protein 2 (DOCK2) is Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. DOCK2 activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK2 may also participate in IL2 transcriptional activation via the activation of RAC2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92608].
UniGene ID
Hs.586174
UniProt ID (eCommerce)
Q92608

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.