human BHLHE40 shRNA silencing AAV

Name 
AAV-h-BHLHE40-shRNA
Cat No 
shAAV-202130
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BHLHE40.

shAAV-202130
AAV-h-BHLHE40-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BHLHE40 (basic helix-loop-helix family member e40). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
basic helix-loop-helix domain containing, class B, 2; BHLHB2; bHLHe40; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; Clast5; DEC1; differentially expressed in chondrocytes 1; differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; enhancer-of-split and hairy-related protein 2; HLHB2; SHARP2; SHARP-2; stimulated by retinoic acid gene 13 protein; STRA13; Stra14
Description (eCommerce)
DEC1 is a basic helix-loop-helix transcription factor that appears to play a role in cell differentiation, proliferation, apoptosis, and the circadian rhythm. DEC1 is able to promote chondrogenic and osteogenic differentiation in mesenchymal stem cells by activating transcription of bone-related genes. When it is overexpressed in cells it can suppress apoptosis by blocking caspase activation and inducing transcription of survivin. DEC1 has also been found to play a role mammalian in circadian rhythm as a suppressor of the CLOCK/BMAL1 promoter.
Description (Vector)
BHLHE40 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation.
Gene ID
8553
Gene Name (eCommerce)
basic helix-loop-helix family member e40
Gene Name (Vector)
basic helix-loop-helix family member e40
Gene Symbol
BHLHE40
HGNC ID
HGNC:1046
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
Protein Name (eCommerce)
Class E basic helix-loop-helix protein 40
RefSeq ID
NM_003670
RefSeq Synonyms
NM_003670, BC082238,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Golgi Apparatus,Neurobiology,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
DEC1 is a basic helix-loop-helix transcription factor that appears to play a role in cell differentiation, proliferation, apoptosis, and the circadian rhythm. DEC1 is able to promote chondrogenic and osteogenic differentiation in mesenchymal stem cells by activating transcription of bone-related genes. When it is overexpressed in cells it can suppress apoptosis by blocking caspase activation and inducing transcription of survivin. DEC1 has also been found to play a role mammalian in circadian rhythm as a suppressor of the CLOCK/BMAL1 promoter.
UniGene ID
Hs.171825
UniProt ID (eCommerce)
O14503

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.