human BGN shRNA silencing AAV

Name
AAV-h-BGN-shRNA

Cat No
shAAV-202122

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BGN.

shAAV-202122

AAV-h-BGN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BGN (biglycan). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DSPG1; PG-S1; PGI; SEMDX; SLRR1A

Description (Vector)

BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.

Gene ID

633

Gene Name (Vector)

biglycan

Gene Symbol

BGN

HGNC ID

HGNC:1044

ORF Size (aa)

1107

ORF Size (bp)

1107 bp

RefSeq ID

NM_001711

RefSeq Synonyms

NM_001711, BC004244, BC002416,

Species

human

UniGene ID

Hs.821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.