human BCAR1 shRNA silencing AAV

Name 
AAV-h-BCAR1-shRNA
Cat No 
shAAV-202011
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BCAR1.

shAAV-202011
AAV-h-BCAR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BCAR1 (BCAR1, Cas family scaffolding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; CASS1; CRKAS; CRK-associated substrate; Crk-associated substrate p130Cas; P130Cas
Description (eCommerce)
BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells.
Description (Vector)
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 (PubMed 17129785)).(supplied by OMIM, May 2009)
Gene ID
9564
Gene Name (eCommerce)
BCAR1, Cas family scaffold protein
Gene Name (Vector)
BCAR1, Cas family scaffolding protein
Gene Symbol
BCAR1
HGNC ID
HGNC:971
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2613
ORF Size (bp)
2613 bp
Protein Name (eCommerce)
Breast cancer anti-estrogen resistance protein 1
RefSeq ID
NM_014567
RefSeq Synonyms
NM_014567, NM_001170721, NM_001170720, NM_001170719, NM_001170718, NM_001170717, NM_001170716, NM_001170715, NM_001170714, BC062556,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Cell Division,Cytoskeleton,EGFR Signaling,Estrogen Signaling,HGF Signaling,Hypoxia,Immunology,Insulin Signaling,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,RAC1 Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells.
UniGene ID
Hs.479747
UniProt ID (eCommerce)
P56945

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.