human ATP6V0D1 shRNA silencing AAV

Name
AAV-h-ATP6V0D1-shRNA

Cat No
shAAV-201752

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ATP6V0D1.

shAAV-201752

AAV-h-ATP6V0D1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATP6V0D1 (ATPase H+ transporting V0 subunit d1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATP6D; ATP6DV; P39; VATX; VMA6; VPATPD

Description (Vector)

ATP6V0D1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.

Gene ID

9114

Gene Name (Vector)

ATPase H+ transporting V0 subunit d1

Gene Symbol

ATP6V0D1

HGNC ID

HGNC:13724

ORF Size (aa)

1056

ORF Size (bp)

1056 bp

RefSeq ID

NM_004691

RefSeq Synonyms

NM_004691, BC008861,

Species

human

UniGene ID

Hs.106876

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.