human ASPSCR1 shRNA silencing AAV

Name
AAV-h-ASPSCR1-shRNA

Cat No
shAAV-201582

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ASPSCR1.

shAAV-201582

AAV-h-ASPSCR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ASPSCR1 (ASPSCR1, UBX domain containing tether for SLC2A4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

alveolar soft part sarcoma chromosomal region candidate gene 1 protein; alveolar soft part sarcoma chromosome region, candidate 1; alveolar soft part sarcoma locus; ASPCR1; ASPL; ASPS; RCC17; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17; renal papillary cell carcinoma protein 17; tether containing UBX domain for GLUT4; TUG; UBX domain protein 9; UBX domain-containing protein 9; UBXD9; UBXN9

Description (eCommerce)

The gene which encodes ASPL (alveolar soft part sarcoma locus) has been identified as a fusion partner of the transcription factor TFE3 in ASPS and renal cell carcinomas.

Description (Vector)

ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Gene ID

79058

Gene Name (eCommerce)

ASPSCR1, UBX domain containing tether for SLC2A4

Gene Name (Vector)

ASPSCR1, UBX domain containing tether for SLC2A4

Gene Symbol

ASPSCR1

HGNC ID

HGNC:13825

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1047

ORF Size (bp)

1047 bp

Protein Name (eCommerce)

Tether containing UBX domain for GLUT4

RefSeq ID

NM_024083

RefSeq Synonyms

NM_024083, NM_001330528, NM_001251888, BC018722, BC006152,

Research Areas

Cancer,Transcriptional Misregulation in Cancer,Transport,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cancer,transcription_translation,cell_biology,cancer,transcription_translation

Species

human

Target Sentence

The gene which encodes ASPL (alveolar soft part sarcoma locus) has been identified as a fusion partner of the transcription factor TFE3 in ASPS and renal cell carcinomas.

UniGene ID

Hs.298351

UniProt ID (eCommerce)

Q9BZE9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.