human CUL2 Over-expression AAV

Name
AAV-h-CUL2

Cat No
AAV-206297

Availability
4-5 weeks

Categories
AAV, Over-Expression

This is an AAV expressing Human CUL2.

AAV-206297

AAV-h-CUL2

Ready-to-use AAV expressing Human CUL2 (cullin 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CUL-2; cullin-2; testis secretory sperm-binding protein Li 238E

Description (eCommerce)

Cullin-2 (Cul2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Cul2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13617].

Gene ID

8453

Gene Name (eCommerce)

cullin 2

Gene Name (Vector)

cullin 2

Gene Symbol

CUL2

HGNC ID

HGNC:2552

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2238

ORF Size (bp)

2238 bp

Protein Name (eCommerce)

Cullin-2

RefSeq ID

NM_003591

RefSeq Synonyms

NM_003591, NM_001324376, NM_001324375, NM_001198779, NM_001198778, NM_001198777, BC110901, BC009591,

Research Areas

Antigen Processing and Presentation,Apoptosis,Cancer,Cell Cycle,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,Immunology,Kidney Cancer,Signal Transduction,Ubiquitination

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,genetics,immunology,infectious_disease,signal_transduction

Species

human

Target Sentence

Cullin-2 (Cul2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Cul2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13617].

UniGene ID

Hs.82919

UniProt ID (eCommerce)

Q13617

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.