human ARHGAP4 shRNA silencing AAV

Name 
AAV-h-ARHGAP4-shRNA
Cat No 
shAAV-201333
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ARHGAP4.

shAAV-201333
AAV-h-ARHGAP4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGAP4 (Rho GTPase activating protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C1; p115; RGC1; rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; RhoGAP4; rho-type GTPase-activating protein 4; SrGAP4
Description (eCommerce)
This gene ARHGAP4 encodes a member of the rhoGAP family, rho GTPase-activating protein 4. Proteins of the rhoGAP family play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus [taken from NCBI Entrez Gene ID: 393].
Description (Vector)
ARHGAP4 encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
393
Gene Name (eCommerce)
Rho GTPase activating protein 4
Gene Name (Vector)
Rho GTPase activating protein 4
Gene Symbol
ARHGAP4
HGNC ID
HGNC:674
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2961
ORF Size (bp)
2961 bp
Protein Name (eCommerce)
Rho GTPase-activating protein 4
RefSeq ID
NM_001666
RefSeq Synonyms
NM_001666, NM_001164741, BC052303,
Research Areas
Apoptosis,Cytoskeleton,GPCR Signaling,Immunology,Neurobiology,NGF Signaling,RAC1 Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
This gene ARHGAP4 encodes a member of the rhoGAP family, rho GTPase-activating protein 4. Proteins of the rhoGAP family play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus [taken from NCBI Entrez Gene ID: 393].
UniGene ID
Hs.701324
UniProt ID (eCommerce)
P98171

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.