human ALDH8A1 shRNA silencing AAV

Name
AAV-h-ALDH8A1-shRNA

Cat No
shAAV-200750

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ALDH8A1.

shAAV-200750

AAV-h-ALDH8A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALDH12; DJ352A20.2

Description (Vector)

This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.

Gene ID

64577

Gene Name (Vector)

aldehyde dehydrogenase 8 family member A1

Gene Symbol

ALDH8A1

HGNC ID

HGNC:15471

ORF Size (aa)

798

RefSeq ID

NM_022568

RefSeq Synonyms

NM_170771, NM_022568, NM_001193480, BC114473, BC113862,

Species

human

UniGene ID

Hs.486520

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.