human AKR1C2 shRNA silencing AAV

Name
AAV-h-AKR1C2-shRNA

Cat No
shAAV-200684

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AKR1C2.

shAAV-200684

AAV-h-AKR1C2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AKR1C2 (aldo-keto reductase family 1 member C2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AKR1C-pseudo; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD

Description (Vector)

AKR1C2 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Gene ID

1646

Gene Name (Vector)

aldo-keto reductase family 1 member C2

Gene Symbol

AKR1C2

HGNC ID

HGNC:385

ORF Size (aa)

972

ORF Size (bp)

972 bp

RefSeq ID

NM_001135241

RefSeq Synonyms

NM_205845, NM_001354, NM_001321027, NM_001135241, BC063574, BC007024,

Species

human

UniGene ID

Hs.567256

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.