human AFF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human AFF1.
shAAV-200530
AAV-h-AFF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human AFF1 (AF4/FMR2 family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AF4; AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; MLLT2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2; PBM1; pre-B-cell monocytic leukemia partner 1; Protein AF-4; Protein FEL; proto-oncogene AF4
Description (eCommerce)
AF4 is a member of the AF4/LAF4/FMR2 (ALF) family of transcription cofactors. It has been identified as part of a translocation [t(4:11)(q21;q23)] found in patients with acute leukemia involving MLL/HRX. AF4 functions as a cofactor of transcriptional elongation and chromatin remodeling.
Gene ID
4299
Gene Name (eCommerce)
AF4/FMR2 family member 1
Gene Name (Vector)
AF4/FMR2 family member 1
Gene Symbol
AFF1
HGNC ID
HGNC:7135
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3636
ORF Size (bp)
3636 bp
Protein Name (eCommerce)
AF4/FMR2 family member 1
RefSeq ID
NM_005935
RefSeq Synonyms
NM_005935, NM_001313960, NM_001313959, NM_001166693, BC114930,
Research Areas
Cancer,Chromatin Remodeling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,cancer,cancer,transcription_translation
Species
human
Target Sentence
AF4 is a member of the AF4/LAF4/FMR2 (ALF) family of transcription cofactors. It has been identified as part of a translocation [t(4:11)(q21;q23)] found in patients with acute leukemia involving MLL/HRX. AF4 functions as a cofactor of transcriptional elongation and chromatin remodeling.
UniGene ID
Hs.480190
UniProt ID (eCommerce)
P51825
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.