human ADNP shRNA silencing AAV

Name 
AAV-h-ADNP-shRNA
Cat No 
shAAV-200481
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ADNP.

shAAV-200481
AAV-h-ADNP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADNP (activity dependent neuroprotector homeobox). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
66
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
activity-dependent neuroprotective protein; activity-dependent neuroprotector; activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; ADNP1; HVDAS; MRD28
Description (eCommerce)
Activity-dependent neuroprotective protein (ADNP) is a factor essential to neurodevelopment. ADNP protein structure consists of nine zinc fingers, a proline-rich region, a nuclear bipartite localization signal, and a homeobox domain profile, suggesting a transcription factor function. ADNP has been shown to differentially associate with chromatin in non-differentiated and neuronal-differentiated cells. ADNP may also mediate the neuroprotective effects of vasoactive intestinal peptide (VIP).
Description (Vector)
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.
Gene ID
23394
Gene Name (eCommerce)
activity dependent neuroprotector homeobox
Gene Name (Vector)
activity dependent neuroprotector homeobox
Gene Symbol
ADNP
HGNC ID
HGNC:15766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3309
ORF Size (bp)
3309 bp
Protein Name (eCommerce)
Activity-dependent neuroprotector homeobox protein
RefSeq ID
NM_015339
RefSeq Synonyms
NM_181442, NM_015339, NM_001347511, NM_001282532, NM_001282531, BC090933, BC075794,
Research Areas
Apoptosis,Gene Expression,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Activity-dependent neuroprotective protein (ADNP) is a factor essential to neurodevelopment. ADNP protein structure consists of nine zinc fingers, a proline-rich region, a nuclear bipartite localization signal, and a homeobox domain profile, suggesting a transcription factor function. ADNP has been shown to differentially associate with chromatin in non-differentiated and neuronal-differentiated cells. ADNP may also mediate the neuroprotective effects of vasoactive intestinal peptide (VIP).
UniGene ID
Hs.570355
UniProt ID (eCommerce)
Q9H2P0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.