human ADH4 shRNA silencing AAV

Name
AAV-h-ADH4-shRNA

Cat No
shAAV-200459

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ADH4.

shAAV-200459

AAV-h-ADH4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADH-2; HEL-S-4

Description (Vector)

ADH4 encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. ADH4 is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.

Gene ID

127

Gene Name (Vector)

alcohol dehydrogenase 4 (class II), pi polypeptide

Gene Symbol

ADH4

HGNC ID

HGNC:252

ORF Size (aa)

1143

ORF Size (bp)

1143 bp

RefSeq ID

NM_000670

RefSeq Synonyms

NM_001306172, NM_001306171, NM_000670, BC022319,

Species

human

UniGene ID

Hs.1219

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.