human ACVRL1 shRNA silencing AAV

Name
AAV-h-ACVRL1-shRNA

Cat No
shAAV-200333

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACVRL1.

shAAV-200333

AAV-h-ACVRL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACVRL1 (activin A receptor like type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I

Description (Vector)

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Gene ID

Gene Name (Vector)

activin A receptor like type 1

Gene Symbol

ACVRL1

HGNC ID

HGNC:175

ORF Size (aa)

1512

ORF Size (bp)

1512 bp

RefSeq ID

NM_000020

RefSeq Synonyms

NM_001077401, NM_000020, BC042637,

Species

human

UniGene ID

Hs.591026

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.