human ABI1 shRNA silencing AAV

Name
AAV-h-ABI1-shRNA

Cat No
shAAV-200123

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ABI1.

shAAV-200123

AAV-h-ABI1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABI1 (abl interactor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Abelson interactor 1; ABI-1; abl interactor 1; abl-binding protein 4; ABLBP4; Abl-interactor protein 1 long; E3B1; eps8 SH3 domain-binding protein; Eps8-binding protein; interactor protein AblBP4; nap1 binding protein; Nap1-binding protein; NAP1BP; spectrin SH3 domain-binding protein 1; SSH3BP; SSH3BP1

Description (eCommerce)

Abl interactor 1 (ABI1) interacts with the ABL1 and/or ABL2 nonreceptor tyrosine kinases and is involved in Ras to Rac signal transduction. ABI1 is also involved in cytoskeletal organization and EGF-induced Erk signaling.

Description (Vector)

ABI1 encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. ABI1 may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.

Gene ID

10006

Gene Name (eCommerce)

abl interactor 1

Gene Name (Vector)

abl interactor 1

Gene Symbol

ABI1

HGNC ID

HGNC:11320

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1431

ORF Size (bp)

1431 bp

Protein Name (eCommerce)

Abl interactor 1

RefSeq ID

NM_005470

RefSeq Synonyms

NM_005470, NM_001178125, NM_001178124, NM_001178123, NM_001178122, NM_001178121, NM_001178120, NM_001178119, NM_001178116, NM_001012752, NM_001012751, NM_001012750, BC024254,

Research Areas

Cytoskeleton,EGFR Signaling,Immunology,Innate Immunity,Neurobiology,PDGF Signaling,RAC1 Signaling,Signal Transduction,Synapse

Research Areas (Faceted)

cell_biology,immunology,neurobiology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.508148

UniProt ID (eCommerce)

Q8IZP0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.