TNF receptor-associated factor 1 Adenovirus
TNF receptor-associated factors 1 and 2 (TRAF1 and TRAF2) are two related proteins that form a heterodimeric complex that associates with the cytoplasmic domain of the tumor necrosis factor (TNF) receptor type 2. A third member of this family, TRAF3 (also designated CD40bp or CRAF1), associates with the cytoplasmic domain of CD40. Three additional members of the TRAF/CRAF family of signaling intermediates include TRAF4 (also designated CART1), TRAF5 and TRAF6.
1600
Ad-TRAF1
Ready-to-use TNF receptor-associated factor 1 Adenovirus. Ad-TRAF1, TNF receptor-associated factor 1, EBI6, TRAF1 adenovirus 1600
Gene Reference Data
Alternate Names
EBI6; MGC:10353
Description (Vector)
TRAF1 is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
7185
Gene Name (Vector)
TNF receptor associated factor 1
Gene Symbol
TRAF1
HGNC ID
HGNC:12031
ORF Size (aa)
1251
RefSeq ID
NM_005658
RefSeq Synonyms
NM_005658, NM_001190947, NM_001190945, BC024145,
Species
human
UniGene ID
Hs.531251
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.