Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization

Alajbegovic A, etc|Biochimica et Biophysica Acta (BBA) - Molecular Cell Research|Lund University

Smooth muscle cell phenotype is associated with changes in miRNA expression profile.

  • Actin/MRTF-A regulate a set of miRNAs (miR-1, miR-22, miR-143, miR-145 and miR-378a) in mouse and human smooth muscle.

  • Actin/MRTF-A-regulated miRNAs are enriched in muscle tissue and associated with the contractile phenotype of smooth muscle cells.

  • Mild aortic dilations are associated with depolymerization of actin and reduced expression of actin/MRTF-A-regulated miRNAs.

    • Alajbegovic A & etc. (2016). Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, doi: 10.1016/j.bbamcr.2016.12.005