AAV with TBG promoter driven EGFP
This AAV expresses EGFP driven by a liver TBG promoter.
TBG is a 0.8kb hybrid promoter based on the human thyroid hormone-binding globulin (TBG) promoter and microglobin/bikunin enhancer. This hybrid promoter has been used for liver-specific transgene expression.
EGFP is derived from the Aequorea GFP with a Excitation/Emission spectrum around 488nm/507nm. It is the most commonly used imaging probe. Other fluorescent proteins with similar emission spectrums are Emerald, and T-Sapphire.
VB1743
AAV-TBG-EGFP
Ready-to-use AAV expressing EGFP driven by a liver TBG promoter. Available in AAV1, AAV2, AAV5, AAV6, AAV8, AAV9, AAV-DJ and other serotypes.
Related Citations
- Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. HG Colaço, etc, (2020), Immunity
- BRD7 deficiency leads to the development of obesity and hyperglycemia. JM Lee, etc, (2019), Scientific Reports
- MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice. YC Kim, etc, (2019), Hepatology
- Autophagy maintains tumour growth through circulating arginine. L Poillet-Perez, etc, (2018), Nature
- Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ß-oxidation. S Seok, etc, (2018), JCI
- MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver. J Kim, etc, (2018), Cell Death & Disease
- ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARg. CB Higgins, etc, (2018), bioRxiv
- Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR¿. CB Higgins, etc, (2018), JCI Insight
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.