rat FZD8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Fzd8.
shADV-294525
Ad-r-FZD8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Fzd8 (frizzled class receptor 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Gene ID
364754
Gene Name (Vector)
frizzled class receptor 8
Gene Symbol
Fzd8
ORF Size (aa)
2055
ORF Size (bp)
2055 bp
RefSeq ID
NM_001044251
RefSeq Synonyms
NM_001044251, BC100088,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.