rat RNF12 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Rlim.
shADV-293970
Ad-r-RNF12-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Rlim (ring finger protein, LIM domain interacting). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Rnf12
Description (Vector)
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. Acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Gene ID
317241
Gene Name (Vector)
ring finger protein, LIM domain interacting
Gene Symbol
Rlim
ORF Size (aa)
1812
ORF Size (bp)
1812 bp
RefSeq ID
NM_001024892
RefSeq Synonyms
NM_001024892, BC097491,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.