rat NEDD4L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Nedd4l.
shADV-293843
Ad-r-NEDD4L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Nedd4l (neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Nedd4-2
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
Gene ID
291553
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene Symbol
Nedd4l
ORF Size (aa)
1323
ORF Size (bp)
1323 bp
RefSeq ID
NM_001008300
RefSeq Synonyms
NM_001008300, BC086371,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.