rat DMAP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Dmap1.
shADV-293190
Ad-r-DMAP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Dmap1 (DNA methyltransferase 1-associated protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Gene ID
298447
Gene Name (Vector)
DNA methyltransferase 1-associated protein 1
Gene Symbol
Dmap1
ORF Size (aa)
1407
ORF Size (bp)
1407 bp
RefSeq ID
NM_001015006
RefSeq Synonyms
NM_001015006, BC092651,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.