rat ARHGEF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Arhgef2.
shADV-293070
Ad-r-ARHGEF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.
Gene ID
310635
Gene Name (Vector)
Rho/Rac guanine nucleotide exchange factor 2
Gene Symbol
Arhgef2
ORF Size (aa)
2958
ORF Size (bp)
2958 bp
RefSeq ID
NM_001012079
RefSeq Synonyms
NM_001012079, BC090078,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.