rat NDFIP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Ndfip1.
shADV-292362
Ad-r-NDFIP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ndfip1 (Nedd4 family interacting protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.
Gene ID
291609
Gene Name (Vector)
Nedd4 family interacting protein 1
Gene Symbol
Ndfip1
ORF Size (aa)
666
ORF Size (bp)
666 bp
RefSeq ID
NM_001013059
RefSeq Synonyms
NM_001013059, BC085887,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.