rat CTNNA1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Ctnna1.
shADV-292196
Ad-r-CTNNA1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ctnna1 (catenin alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Catna1
Description (Vector)
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Gene ID
307505
Gene Name (Vector)
catenin alpha 1
Gene Symbol
Ctnna1
ORF Size (aa)
2727
ORF Size (bp)
2727 bp
RefSeq ID
NM_001007145
RefSeq Synonyms
NM_001007145, BC085789,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.