rat ARHGAP24 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Arhgap24.
shADV-292193
Ad-r-ARHGAP24-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Arhgap24 (Rho GTPase activating protein 24). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DR-NR#2
Description (Vector)
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Gene ID
305156
Gene Name (Vector)
Rho GTPase activating protein 24
Gene Symbol
Arhgap24
ORF Size (aa)
1971
ORF Size (bp)
1971 bp
RefSeq ID
NM_001012032
RefSeq Synonyms
NM_001012032, BC085797,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.