rat CCND3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Ccnd3.
shADV-292161
Ad-r-CCND3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ccnd3 (cyclin D3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Gene ID
25193
Gene Name (Vector)
cyclin D3
Gene Symbol
Ccnd3
ORF Size (aa)
879
RefSeq ID
NM_012766
RefSeq Synonyms
NM_012766, BC089819, BC085763,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.