rat DDX5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Ddx5.
shADV-291164
Ad-r-DDX5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ddx5 (DEAD-box helicase 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.
Gene ID
287765
Gene Name (Vector)
DEAD-box helicase 5
Gene Symbol
Ddx5
ORF Size (aa)
1848
ORF Size (bp)
1848 bp
RefSeq ID
NM_001007613
RefSeq Synonyms
NM_001007613, BC079036,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.