rat CYLD shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Cyld.
shADV-290791
Ad-r-CYLD-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Cyld (CYLD lysine 63 deubiquitinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LRRGT00003; Rp1; Rp1h
Description (Vector)
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity).
Gene ID
312937
Gene Name (Vector)
CYLD lysine 63 deubiquitinase
Gene Symbol
Cyld
ORF Size (aa)
2862
ORF Size (bp)
2862 bp
RefSeq ID
NM_001017380
RefSeq Synonyms
NM_001017380, BC082001,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.