rat MMP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Mmp2.
shADV-290730
Ad-r-MMP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Mmp2 (matrix metallopeptidase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro|Function: PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Gene ID
81686
Gene Name (Vector)
matrix metallopeptidase 2
Gene Symbol
Mmp2
ORF Size (aa)
1989
ORF Size (bp)
1989 bp
RefSeq ID
NM_031054
RefSeq Synonyms
NM_031054, BC074013,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.