rat GM2A shRNA silencing Adenovirus

Name
Ad-r-GM2A-shRNA

Cat No
shADV-290666

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Gm2a.

shADV-290666

Ad-r-GM2A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Gm2a (GM2 ganglioside activator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

Gene ID

282838

Gene Name (Vector)

GM2 ganglioside activator

Gene Symbol

Gm2a

ORF Size (aa)

600

RefSeq ID

NM_172335

RefSeq Synonyms

NM_172335, BC072474,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.