rat P4HB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat P4hb.
shADV-290497
Ad-r-P4HB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat P4hb (prolyl 4-hydroxylase subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PDI; PDIR
Description (Vector)
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Gene ID
25506
Gene Name (Vector)
prolyl 4-hydroxylase subunit beta
Gene Symbol
P4hb
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
RefSeq ID
NM_012998
RefSeq Synonyms
NM_012998, BC061857,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.