rat ADAM15 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Adam15.
shADV-290391
Ad-r-ADAM15-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Adam15 (ADAM metallopeptidase domain 15). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MDC15; tMDCVI
Description (Vector)
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Gene ID
57025
Gene Name (Vector)
ADAM metallopeptidase domain 15
Gene Symbol
Adam15
ORF Size (aa)
2595
ORF Size (bp)
2595 bp
RefSeq ID
NM_020308
RefSeq Synonyms
NM_020308, BC061796,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.