rat ENSA shRNA silencing Adenovirus

Name
Ad-r-ENSA-shRNA

Cat No
shADV-290062

Availability
Immediate

This is an Adenovirus expressing shRNA for silencing of Rat Ensa.

shADV-290062

Ad-r-ENSA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ensa (endosulfine alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Gene ID

60334

Gene Name (Vector)

endosulfine alpha

Gene Symbol

Ensa

ORF Size (aa)

354

RefSeq ID

NM_021842

RefSeq Synonyms

NM_021842, NM_001033974, BC059135,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.